Immunology and Cell Biology (1988) 66, 153–157; doi:10.1038/icb.1988.19
1Department of Microbiology, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia
Received 8 October 1987; Accepted 14 December 1987.
A-strain influenza virus A/JAP (H2N2) was tested for its ability to induce cytotoxic T cells (Tc) after being rendered non-infectious by either UV or gamma irradiation. Gamma-irradiated virus proved to be more efficient than UV-inactivated virus in priming for a memory Tc cell response or in boosting memory spleen cells in vitro. Most importantly, -inactivated, but not UV-inactivated, A/JAP immunized animals survived lethal challenge with heterologous (A/PC(H3N2), A/WSN(H1N1)) virus as effectively as mice primed with infectious virus.
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